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The main field should be able to take wildcards (i.e. '*' character or space that can represent any letter). Additionally, a couple of other fields for prefixes and suffixes should be available, which can be used to solve word games such as scrabble.
Design-wise I don't anything too elaborate, I will work on that part, in the meantime just use a free template, a blank page or something... as long as the input fields and results are presented in a way that make sense it's okay.