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Check breakdown pathway of 245 drugs from website and enter in excel - repost

€30-250 EUR

Completed
Posted over 10 years ago

€30-250 EUR

Paid on delivery
I am looking for someone with preferably (but not necessarily) either medical, biological or pharmacological education to check a list of 245 drugs on the website [login to view URL] and to enter the breakdown pathway into an excel file. The breakdown pathway is always one of 7 different enzymes (CYP2D6, 2C9, 2C19, 3A4, 3A5, 2E1, 1A2) and the breakdown percentage of each drug needs to be entered in the excel. Example text from website: Sunitinib is metabolized primarily by the cytochrome P450 enzyme, CYP3A4, to produce its primary active metabolite, which is further metabolized by CYP3A4. >>>>This would result in the entry in the excel under "CYP3A4 100% Example text from website: Hepatic. Zileuton and its N-dehydroxylated metabolite are oxidatively metabolized by the cytochrome P450 isoenzymes 1A2, 2C9 and 3A4. >>>>This would result in the entry in the excel under 1A2 with 33%, 2C9 with 33% and 2A4 with 33% Example text from website: Hepatic - estimated 50% metabolized by CYP3A4 and 50% metabolized independent of cytochrome P450 >>>>This would result in an entry in the excel sheet under CYP3A4 of 50% In addition, whether or not the drug is a prodrug (a drug that needs to be modified by an enzyme before showing its effect) needs to be noted. Hint: allways ignore information about 2D6 and 2C19 ultrarapid and rapid metabolizers... We are not interested in this information. Example: The drug amitriptyline Link: https://www.pharmgkb.org/drug/PA448385#tabview=tab0&subtab=31 Question: What is the primary route of breakdown? (CYP2D6, 2C9, 2C19, 3A4, 3A5, 2E1, 1A2) Text that contains answer: Summary The CPIC Dosing Guideline for amitriptyline recommends an alternative drug for CYP2D6 or CYP2C19 ultrarapid metabolizers and for CYP2D6 poor metabolizers. Consider a 50% dose reduction for CYP2C19 poor metabolizers and a 25% dose reduction for CYP2D6 intermediate metabolizers. Question 2: is it a Prodrug? Text that contains the answer: Biotransformation Exclusively hepatic, with first pass effect. Amitriptyline is demethylated in the liver to its primary active metabolite, nortriptyline. answer: Yes, it is a prodrug. The aim is to make a list of drugs with the breakdown enzymes. I will then use this list to see which drugs are not broken down correctly if one of these enzymes is defective. You need to have some background in this field to bid. I will also award to 2 independent bidders and compare the results, so accurate work is required. Milestones will be uploaded in full, payment after completion.
Project ID: 5364963

About the project

13 proposals
Remote project
Active 10 yrs ago

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Dear sir,I see your project description. i can do the job accurate perfect. recent i create a new team & totally free my team. so need lots of [login to view URL] team are 5 person everyone have lots of experience with minimum 3 years about Copy Typing, Data Entry, Data Processing,Data Mining, Web Scraping, Web Search& Excel. The work will be accurate perfect in time. sir can you give a chance to work with you. Waiting for your reply. Thanks
€50 EUR in 1 day
4.8 (176 reviews)
6.1
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Hi Being honest i am a student of bioformatics and i am interested in doing that work. I can provide you the results in almost 3 days with 100% accuracy. If you think i have cheated you , then you have no need to pay me. i would wait for your response thanks
€30 EUR in 2 days
4.9 (5 reviews)
2.4
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€30 EUR in 3 days
4.7 (19 reviews)
3.5
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13 freelancers are bidding on average €149 EUR for this job
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"Dear employer, I am a highly trained Data Entry,Research, Web search, Web scrape, Product Add Any Type Of Card, Expert with great knowledge of Excel and all Social Networks. Please check my profile and ask me if you have any quest?? My bid is optional and I will let you chose the price that suits you best!!! I just want to prove my skills and have a long-term employer in you!!! Ready to work right now.Jewel."
€144 EUR in 3 days
4.9 (1287 reviews)
8.8
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sir, i am highly interested and dedicated to do this task. let's start. i am awaiting for your positive reply. thanks
€150 EUR in 5 days
4.9 (926 reviews)
8.1
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Hi, I can do this job efficiently. I am flexible about working time and money. I believe work speaks better than words. Hope to have a positive response. Good day, Anamika
€155 EUR in 5 days
4.8 (243 reviews)
6.6
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5.0 (3 reviews)
3.3
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3.7 (2 reviews)
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Dear Sir, I have been in this industry for 10 years and such jobs are my daily practice. This is my first time on this site and hence you can see that I do not have any ratings/testimonials to show you. I can assure you that if you work with me once, you will always work with me for these kind of projects.
€111 EUR in 3 days
0.0 (0 reviews)
0.0
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I am a perfect candidate for this project as I have a good knowledge of medicine and also biological sciences. I am a registered health care professional in Pakistan, served as lecturer in the Islamia University of Bahwalpur and taught medical subjects to undergraduate students. Currently I am proceeding my MS leading to PhD studies at Middle east Technical University, Ankara, Turkey.
€111 EUR in 7 days
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Flag of AUSTRIA
Salzburg, Austria
5.0
327
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Member since Jul 4, 2011

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